Combined Therapy of Sildenafil and Beraprost Improves Arrhythmogenicity Through Connexin 43 Expression and Action Potential Dispersion in Monocrotaline-Induced Rat Pulmonary Hypertension
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چکیده
منابع مشابه
Rosuvastatin, sildenafil and their combination in monocrotaline-induced pulmonary hypertension in rat.
There is considerable interest in the pleiotropic effects of statins and their potential role in the treatment of pulmonary hypertension. Previous experimental findings indicate that a combination of lipophilic statins with phosphodiesterase type-5 inhibitor, sildenafil, can offer preventive effects on rat monocrotaline-induced pulmonary hypertension. The present study is aimed to assess whethe...
متن کاملCombination therapy with fasudil and sildenafil ameliorates monocrotaline-induced pulmonary hypertension and survival in rats.
BACKGROUND Pulmonary hypertension (PH) is a fatal disease characterized by pulmonary artery (PA) remodeling, elevated PA pressure and right ventricular (RV) failure. It has been previously demonstrated that treatment with a Rho-kinase inhibitor, fasudil, ameliorates PH in animal models. Here, whether combination therapy with fasudil and sildenafil further ameliorates PH in rats was examined. ...
متن کاملChronic sildenafil treatment inhibits monocrotaline-induced pulmonary hypertension in rats.
Sildenafil, a phosphodiesterase 5 inhibitor, is currently under investigation for therapy of pulmonary hypertension. This study was designed to investigate chronic effects of sildenafil in monocrotaline (MCT)-induced pulmonary hypertension in rats. Four weeks after a single subcutaneous injection of MCT, the animals displayed nearly threefold elevated pulmonary artery pressure and vascular resi...
متن کاملN-acetylcysteine improves established monocrotaline-induced pulmonary hypertension in rats
BACKGROUND The outcome of patients suffering from pulmonary arterial hypertension (PAH) are predominantly determined by the response of the right ventricle to the increase afterload secondary to high vascular pulmonary resistance. However, little is known about the effects of the current available or experimental PAH treatments on the heart. Recently, inflammation has been implicated in the pat...
متن کاملCombination therapy with oral sildenafil and beraprost for pulmonary arterial hypertension associated with CREST syndrome.
Pulmonary arterial hypertension (PAH) is commonly associated with CREST (Calcinosis, Raynaud phenomenon, Esophageal motility disorders, Sclerodactyly, and Telangiectasia) syndrome. Sildenafil, an oral phosphodiesterase type-5 inhibitor, may offer benefits in the pharmacological management of PAH. However, little is known about the long-term hemodynamic effects of sildenafil, and the potential r...
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ژورنال
عنوان ژورنال: Journal of Arrhythmia
سال: 2011
ISSN: 1880-4276,1883-2148
DOI: 10.4020/jhrs.27.op44_3